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Journal of Medical Chemical, Biological and Radiological Defense

Archives of Related Literature  |  Nerve Agents

Tutorial: Clinical Considerations in the Use of Pyridostigmine Bromide as Pretreatment for Nerve-Agent Exposure. James M. Madsen, Charles G. Hurst, Roger MacIntosh, James A. Romano, Jr. USAMRICD, Aberdeen Proving Ground MD, January 2003. [PDF]

Low concentrations of pyridostigmine prevent soman-induced inhibition of GABAergic transmission in the central nervous system: involvement of muscarinic receptors. J Pharmacol Exp. Ther. 2003 Jan 304(1):254-65 Santos MD, Pereira EFm Arcava T, Castro NG, Gawcett WP, Randall WR, Albuquerque EX.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12490599&dopt=Abstract

Inhibition of neurotransmitter release by peptides that mimic the N-terminal domain of SNAP-25. J Protein Chem. 2003 Feb 22(2):147-53 Apland JP, Adler M, Oyler GA.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12760419&dopt=Abstract

Control of nerve agent-induced seizures is critical for neuroprotection and survival small star, filled. Toxicol Appl Pharmacol. 2003 Apr 15 188(2):69-80 Shih TM, Duniho SM, McDonough JH.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12691725&dopt=Abstract&itool=iconabstr

A theoretical expression for the protection associated with stoichiometric and catalytic scavengers in a single compartment model of organophosphorus poisoning. Math Biosci. 2003 Feb;181(2):133-43 Sweeney RE, Maxwell DM.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12445758&dopt=Abstract&itool=iconabstr

Field verification of Test-mate ChE. Mil Med. 2003 Apr;168(4):314-9 Taylor PW, Lukey BJ, Clark CR, Lee RB, Roussel RR.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12733677&dopt=Abstract&itool=iconabstr

The determination of biperiden in plasma using gas chromatography mass spectrometry: pharmacokinetics after intramuscular administration to guinea pigs. Biomed Chromatogr. 2002 Feb;16(1):47-55 Capacio BR, Caro ST, Smith JR, Byers CE.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11816011&dopt=Abstract&itool=iconabstr

Quantitation of organophosphorus nerve agent metabolites in human urine using isotope dilution gas chromatography-tandem mass spectrometry. J Anal Toxicol. 2002 Jan-Feb;26(1):6-10 Driskell WJ, Shih M, Needham LL, Barr DB.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11888020&dopt=Abstract&itool=iconabstr

Response of rats to low levels of sarin. Toxicol Appl Pharmacol. 2002 Oct 15;184(2):67-76 Henderson RF, Barr EB, Blackwell WB, Clark CR, Conn CA, Kalra R, March TH, Sopori ML, Tesfaigzi Y, Menache MG, Mash DC.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12408950&dopt=Abstract&itool=iconabstr

The dose-response effects of repeated subacute sarin exposure on guinea pigs. Pharmacol Biochem Behav. 2002 Jul;72(4):835-45 Hulet SW, McDonough JH, Shih TM.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12062573&dopt=Abstract&itool=iconabstr

Oligomeric states of the detergent-solubilized human serum paraoxonase (PON1). J Biol Chem. 2002 Sep 6;277(36):33386-97. Epub 2002 Jun 21 Josse D, Ebel C, Stroebel D, Fontaine A, Borges F, Echalier A, Baud D, Renault F, Le Maire M, Chabrieres E, Masson P.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12080042&dopt=Abstract&itool=iconabstr

Effects of anticholinergics on serial-probe recognition accuracy of rhesus macaques (Macaca mulatta). Pharmacol Biochem Behav. 2002 Nov;73(4):829-34 Myers TM, Galbicka G, Sipos ML, Varadi S, Oubre JL, Clark MG.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12213528&dopt=Abstract&itool=iconabstr

Progress on the road to new nerve agent treatments. J Appl Toxicol. 2001 Dec;21 Suppl 1:S43-6 Broomfield CA, Kirby SD.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11920919&dopt=Abstract&itool=iconabstr

Intramuscular diazepam pharmacokinetics in soman-exposed guinea pigs. J Appl Toxicol. 2001 Dec;21 Suppl 1:S67-74 Capacio BR, Whalley CE, Byers CE, McDonough JH.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11920923&dopt=Abstract&itool=iconabstr

Protective action of the serine protease inhibitor N-tosyl-L-lysine chloromethyl ketone (TLCK) against acute soman poisoning. J Appl Toxicol. 2001 Jul-Aug;21(4):293-6 Cowan FM, Broomfield CA, Lenz DE, Shih TM.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11481662&dopt=Abstract&itool=iconabstr

Histopathologic changes in the brain, heart, and skeletal muscle of rhesus macaques, ten days after exposure to soman (an organophosphorus nerve agent). Comp Med. 2000 Apr;50(2):133-9 Britt JO Jr, Martin JL, Okerberg CV, Dick EJ Jr.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10857003&dopt=Abstract&itool=iconabstr

Low concentrations of pyridostigmine prevent soman-induced inhibition of GABAergic transmission in the central nervous system: involvement of muscarinic receptors. Santos MD, Pereira EF, Aracava Y, Castro NG, Fawcett WP, Randall WR, Albuquerque EX.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12490500&dopt=Abstract&itool=iconabster